Activation Of Akt/mtor Pathway In Response To Acute Exercise In Rats Of Different Trained Status

minutes after completing the submaximal test. Predicted VO2 was calculated from a submaximal treadmill test. An SVR exercise response coefficient (ERC) was derived and subjects were then categorized as normal response (NR) to exercise or abnormal response (AR) to exercise. Comparisons between groups were determined using ANOVA. RESULTS: The AR group indicated a significant blunted or even elevated SVR coefficient (1.092+.09 p<.05) compared to the NR group (.853+.098). The LAEI was significantly different between the groups (16.25 +3.68 mL/mm Hg x 10 vs 13.58+3.34 mL/mm Hg x 10).There were also significant differences (p.<05) in the post exercise responses of ejection time (284.06+19.5 ms vs 314.06+24.93 ms), systolic BP (120.58+10.73 mmHg vs 114.43+10.70mmHg), and diastolic BP (70.65+7.38 mmHg vs 66.24+7.3 mmHg). CONCLUSIONS: The lack of response may be due to the poor fitness level. Although fitness was not found to be significant between the groups the fitness levels were poor. Poor fitness due to inactivity decreases vasodilator function in the smooth muscles associated with the smaller arterioles at the tissue level. The results of the lack of vasodilation may be the cause for the reduced ejection time due to the increased afterload.